Separate and combined effects of the cannabinoid agonists nabilone and Δ9-THC in humans discriminating Δ9-THC
نویسندگان
چکیده
منابع مشابه
High-throughput toxicological analysis of Δ9-THC and 11-nor-9-carboxy-Δ9-THC by LC/MS/MS
A new high-throughput liquid chromatography / tandem mass spectrometry (LC-MS/MS) method for the quantification of Δ-tetrahydrocannabinol (THC) in suspect plant material and of its principal metabolite, 11-nor-9carboxy-Δ-tetrahydrocannabinol (THC-COOH), in human urine was developed and validated. The separation was performed on a Zorbax SB-C18 column under isocratic conditions using a mixture o...
متن کاملDefault Mode Network in the Effects of Δ9-Tetrahydrocannabinol (THC) on Human Executive Function
Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well as in psychiatric disorders characterized by cognitive deficits, such as schizophrenia. Executive function appears to be associated with both modulation of active networks and inhibition of activity in the default mode network. In the present study, we ...
متن کاملChronic Δ9-THC Exposure Differently Affects Histone Modifications in the Adolescent and Adult Rat Brain
Adolescence represents a vulnerable period for the psychiatric consequences of delta9-tetrahydrocannabinol (Δ⁸-THC) exposure, however, the molecular underpinnings of this vulnerability remain to be established. Histone modifications are emerging as important epigenetic mechanisms involved in the etiopathogenesis of psychiatric diseases, thus, we investigated the impact of chronic Δ⁸-THC exposur...
متن کاملΔ9-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling
Marijuana has been used for thousands of years as a treatment for medical conditions. However, untoward side effects limit its medical value. Here, we show that synaptic and cognitive impairments following repeated exposure to Δ(9)-tetrahydrocannabinol (Δ(9)-THC) are associated with the induction of cyclooxygenase-2 (COX-2), an inducible enzyme that converts arachidonic acid to prostanoids in t...
متن کاملLong-lasting alterations of hippocampal GABAergic neurotransmission in adult rats following perinatal Δ9-THC exposure.
The long-lasting effects of gestational cannabinoids exposure on the adult brain of the offspring are still controversial. It has already been shown that pre- or perinatal cannabinoids exposure induces learning and memory disruption in rat adult offspring, associated with permanent alterations of cortical glutamatergic neurotransmission and cognitive deficits. In the present study, the risk of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug and Alcohol Dependence
سال: 2011
ISSN: 0376-8716
DOI: 10.1016/j.drugalcdep.2010.11.019